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These data suggest that cannabinoids may have therapeutic opportunity in neuropathic suffering, and that this outcome is mediated from the CB1 receptor.

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Neuropathic agony is outlined as ‘discomfort initiated or because of a Principal lesion or dysfunction in the anxious system' (Merskey & Bogduk, 1994) and is a place of mainly unmet therapeutic need.

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This result was prevented by co-administration on the CB1 receptor antagonist SR141716a, but not by co-administration from the CB2 receptor antagonist SR144528, suggesting this action of WIN55,212-two is mediated by way of

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